HORSE SHOE KIDNEY

Horseshoe kidney, also known as renal fusion, is a congenital disorder affecting about 1 in 400 people^[1]. In this disorder, the patient's kidneys fuse together to form a horseshoe-shape during development in the womb.

Fusion abnormalities of the kidney can be categorized into two groups: horseshoe kidney and crossed fused ectopia. The horseshoe kidney is the most common renal fusion anomaly.

MARFAN SYNDROME

Marfan syndrome (also called Marfan's syndrome) is a genetic disorder of the connective tissue.

It is sometimes inherited as a dominant trait. It is carried by a gene called FBN1, which encodes a connective protein called fibrillin-1.People have a pair of FBN1 genes. Because it is dominant, people who have inherited one affected FBN1 gene from either parent will have Marfan's. This syndrome can run from mild to severe.

People with Marfan's are typically tall, with long limbs and long thin fingers.

The most serious complications are the defects of the heart valves and aorta. It may also affect the lungs, eyes, the dural sac surrounding thespinal cord, skeleton and the hard palate.

In addition to being a connective protein that forms the structural support for tissues outside the cell, the normal fibrillin-1 protein binds to another protein, transforming growth factor beta (TGF-β). TGF-β has deleterious effects on vascular smooth muscle development and the integrity of the extracellular matrix. Researchers now believe that secondary to mutated fibrillin there is excessive TGF-β at the lungs, heart valves, and aorta, and this weakens the tissues and causes the features of Marfan syndrome. ^[4]Since angiotensin II receptor blockers (ARBs) also reduce TGF-β, they have tested this by giving ARBs (losartan, etc.) to a small sample of young, severely affected Marfan syndrome patients. In some patients, the growth of the aorta was indeed reduced.

For more info,click on the given link :

http://en.wikipedia.org/wiki/Marfan_syndrome

ACRODYSOSTOSIS

Definition

Acrodysostosis is an extremely rare disorder that is present at birth (congenital). People with this condition have problems in the bones of the hands, feet, and nose, and mental retardation.

Causes

Most patients with acrodysostosis have no family history of the disease. However, sometimes the condition is passed down from parent to child. Parents with the condition have a 1 in 2 chance of passing the disorder to their children.

There is a slightly greater risk with fathers who are older.

Symptoms

• Frequent middle ear infections
• Growth problems, short arms and legs
• Hearing problems
• Mental deficiency
• Unusual looking face

Exams and Tests

A physical exam confirms this disorder.

Findings may include:

• Advanced bone age
• Bone deformities in hands and feet
• Delays in growth
• Problems with the skin, genitals, teeth, and skeleton
• Short arms and legs with small hands and feet
• Short head, measured front to back (brachycephaly)
• Short height
• Small, upturned broad nose with flat bridge
• Unusual features of the face (short nose, open mouth, jaw that sticks out)
• Unusual head
• Wide-spaced eyes (hypertelorism), sometimes with extra skin fold at corner of eye

In the first months of life, x-rays may show spotty calcium deposits, called stippling, in bones (especially the nose). Infants may also have:

• Abnormally short fingers and toes (brachydactyly)
• Early growth of bones in the hands and feet
• Short bones
• Shortening of the forearm bones near the wrist

Treatment

Treatment depends on the physical and mental problems that occur.

Orthopedic care, early intervention, and special education are recommended.

Outlook (Prognosis)

Problems depend on the degree of skeletal involvement and mental retardation. In general, patients do relatively well.

Possible Complications

• Arthritis
• Carpal tunnel syndrome
• Worsening range of movement in the spine, elbows, and hands

When to Contact a Medical Professional

Call your health care provider if your child seems to be growing or developing slowly or abnormally, or if you notice physical abnormalities in your infant.

Prevention

Consider genetic counseling to help with diagnosis, testing, and identifying risk.

COBB'S ANGLE

Cobb's angle, a measurement used for evaluation of curves in scoliosis on an AP radiographic projection of the spine . When assessing a curve the apical vertebra is first identified; this is the most likely displaced and rotated vertebra with the least tilted end plate. The end/transitional vertebra are then identified through the curve above and below. The end vertebra are the most superior and inferior vertebra which are least displaced and rotated and have the maximally tilted end plate. A line is drawn along the superior end plate of the superior end vertebra and a second line drawn along the inferior end plate of the inferior end vertebra. If the end plates are indistinct the line may be drawn through the pedicles. The angle between these two lines (or lines drawn perpendicular to them) is measured as the Cobb angle. In S-shaped scoliosis where there are two contiguous curves the lower end vertebra of the upper curve will represent the upper end vertebra of the lower curve. Because the Cobb angle reflects curvature only in a single plane and fails to account for vertebral rotation it may not accurately demonstrate the severity of three dimensional spinal deformity. As a general rule a Cobb angle of 10 is regarded as a minimum angulation to define scoliosis.

Proud of Neuro-Pathology

Dr Anshu Gupta

Associate Professor

MBBS , MD (Pathology)

O.I/C , Emergency Lab

Institute of Human Behaviour and Allied Sciences,Delhi

This article describe about the life achievement of that person who is completely dedicated for the patient care services in neuro-pathology field. A person not only hard working and sincere but helpful to the needy patients and friendly ,supportive and co-operative with her collegues . This inspired the other persons too ,who connected to the patient care services directly or indirectly.

Dr Anshu Gupta's profile:-

Dr Anshu Gupta graduated from Pt.BD Sharma Post Graduate Institute of Medical Sciences,Rohtak,India. She did her MD in Pathology from the same college. Dr Anshu Gupta joined Pt. B.D Sharma Post Graduate Institute of Medical Sciences as a Assistant Professor and presently giving her services as a Associate Professor and Officer In Charge of Emergency Laboratory in the Department of Neuro-pathology at Institute of Human Behavior and Allied Sciences, Dilshad Garden, Delhi .Her research papers and articles published in national and international journals like Indian Journal of Pathology and Microbiology , Springer Journal , Indian Journal of Urology ,Wiley InterScience etc

Important Neuro-Pathology Facilities available at IHBAS:

This Institute is one of the reputed Institute of Northern India for the treatment of different types of Mental disorders e.g Epilepsy and its different types,Dementia,Alzhiemers,Cerebal Palsy,Depression ,Movement Disorders,Fits,Tremors , Brain Tumors,Mental Retardation etc. IHBAS has a facility of different Neuro-Patholoical Biological instruments like optical Microscope etc.All instruments are of international Standards for study the human tumors using Histopathology and Cytology procedures.Urine and Blood Characterization performed in Neuro-Pathology Laboratory from well trained Technicians and Consultants on a modern instruments. Beside this IHBAS has a facility of high power 3T-MRI (3 tesla=30,000 guass) which can provide the better resolution of the soft tissues than normal MRI.It is available only at few parts of Delhi.

Some of her famous published articles and research papers in leading journals:-

Giant appendicular schwannoma in a child in Indian Journal Pathology Microbiology - 52(2), april-june 2009

A case report on Acute pancreatitis: a rare cause of acute abdomen in pregnancy Volume 279, Number 4 / April, 2009 published in Springer Journal: Archives of Gynecology and Obstetrics

Obstructive anuria due to blood clot : Volume 278, Number 4 / October, 2008 published in Springer Journal : Archives of Gynecology and Obstetrics

A Case Report on Testicular granulosa cell tumor, adult type :Year : 2008 | Volume : 51 | Issue : 3 |Page : 405-406 published in 2008 Indian Journal of Pathology and Microbiology

Adrenal angiomyolipoma: A rare entity Indian Journal of Urology in July-Sept 2007

A case report on Ovarian actinomycosis in absence of intrauterine contraceptive device: an unusual presentation published in Wiley Interscience in 2002:

For Queries Regarding Neuro-Pathology Imaging ,feel free to Contact from the concern Person:-

Dr Anshu Gupta

Associate Professor

MBBS , MD (Pathology)

O.I/C , Emergency Lab

IHBAS,,Delhi or in Academic Block in Room No 212

Note:

!!! Mental Illness is Treatable
!!! Contact your Physician if any side effect arise from the Medication.

PROUD OF NEUROLOGY

Dr. Vibhor Pardasani

MD(Internal Medicine), D.M (Neurology)
Neurology Consultant : Seven Hills Hospital , Mumbai

This article describe about the life achievement of that person who is completely dedicated for the patient care services in neurological field. A person not only hard working and sincere but helpful to needy patients. This inspired the other persons too ,who connected to the patient care services directly or indirectly .

Dr Vibhor Pardasani's profile:-

Dr. Vibhor Pardasani is a neurologist trained at the All India Institute of Medical Sciences, New Delhi. A graduate from Maulana Azad Medical College, New Delhi Dr. Pardasani pursued his post-graduation in Internal Medicine at the Lady Hardinge Medical College, New Delhi. He has served as Assistant Professor in Neurology at the Institute of Human Behaviour and Allied Sciences, New Delhi. He holds special interests in the management of stroke, refractory epilepsy and sleeps disorders; and has undergone special training in sleep medicine.

Dr. Pardasani has worked as a visiting neurologist at the King's College Hospital, London, where he was actively involved in the evaluation and management of difficult-to-treat epilepsy patients. He has been the forerunner in the organisation of several public awareness programmes for common neurological disorders such as stroke, epilepsy and Parkinsonism.

His areas of research include functional MRI in autism, chronotypes and sleep-wakefulnesspatterns in young adults and functional stimulation in lesion-negative refractory epilepsy. He has many international and national publications to his credit. Dr. Pardasani is a member of Indian Academy of Neurology, the Neurological Society of India and the Indian Epilepsy Society.

Some of his famous published research papers in leading journals:-

(1) :Azithromycin-induced myasthenic crisis:

Reversibility with calcium gluconate in 2009 published in neurology india published in Neurology India, Year 2009, Volume 57, Issue 3 and Indian Journal of Pharmaceutical Sciences

(2) :Finger Drop Following a Potassium Drop in JAPI • MAY 2009 • VOL. 57

(3):Attitude, Anxiety and Care Giver's Burden of the Relatives of ICU Patients: A Pilot Study

Published in Indian Association of Clinical Psychologists

(4):An Unusual Clinical Profile of Visceral Leishmaniasis

Published in Journal of Indian Academy of Clinical Medicine Vol. 5 No. 2

(5): Gave his vital Lecture on EEG at AIIMS on "WORKSHOPS ON EPILEPSY AND EEG"


Note:

!!! Mental Illness is Treatable
!!! Contact your Physician if any side effect arise from the Neuro-Medication.

EXCERCISES FOR SCOLIOSIS PATIENTS:-

Note : Please do this under the supervision of trained Physiotherapist

For Scoliosis excerscices Video ,please click on the given link
http://www.iscoliosis.com/video.html?reload=main&filename=exercise-legarm&videocookie=56.wmv

Neuro Workshop

THIRD SERC SCHOOL IN NEUROSCIENCE
IMAGING THE NERVOUS SYSTEM

ApplicaCons are invited from PhD Scholars, Post Doctoral Fellows and Young Faculty members *

Last Date : 30th September 2009!

Program On :- 7 – 21 December 2009!
Venue: IISER, Pune.!

For Course Information and Applicacation Details:-
Please visit: http://www.iiserpune.ac.in/~neuroschool2009
Email: neuroschool2009@iiserpune.ac.in

Indian Institute of Science Educa5on and Research,
Central Tower, Sai Trinity Building, Garware Circle, Sutarwadi, Pashan, Pune 411021, INDIA
Tel: +91 (0)20 2590 8000

CHARACTERIZATION OF INFECTED TISSUES

Histopathology refers to the microscopic examination of tissue in order to study the manifestations of disease. Specifically, in clinical medicine, histopathology refers to the examination of a biopsy or surgical specimen by a pathologist, after the specimen has been processed and histological sections have been placed onto glass slides.

Collection of tissues

Histopathological examination of tissues starts with surgery, biopsy, or autopsy. The tissue is removed from the body or plant, and then placed in a fixative which stabilizes the tissues to prevent decay. The most common fixative is formalin (10% formaldehyde in water).

Preparation for histology

The tissue is then prepared using histology procedures for viewing under a microscope using one of two method of fixation - chemical fixation or frozen section.

Chemical Fixation Tissue Processing

The samples are transferred to a cassette, a container designed to allow reagents to freely act on the tissue inside. This cassette is immersed in multiple baths of progressively more concentrated ethanol, to dehydrate the tissue, followed by toluene or xylene, and finally extremely hot liquid (usually paraffin). During this 12 to 16 hour process, paraffin will replace the water in the tissue, turning soft, moist tissues into a sample miscible with paraffin, a type of wax. This process is known as tissue processing.

The processed tissue is then taken out of the cassette and set in a mold. Through this process of embedding, additional paraffin is added to create a paraffin block which is attached to the outside of the cassette.

The process of embedding then allows the sectioning of tissues into very thin (2 - 7 micrometer) sections using a microtome. The microtome slices the tissue ready for microscopic examination. The slices are thinner than the average cell, and are layered on a glass slide for staining.

Frozen Section Tissue Processing

The second method of histology processing is called frozen section histology. In this method, the tissue is frozen and sliced thinly using a microtome mounted in a refrigeration device called the cryostat. The thin frozen sections are mounted on a glass slide, dried, and stained using the same staining techniques as traditional wax embedded sections. The advantages of this method is rapid processing time, less equipment requirement, and less need for ventilation in the laboratory. The disadvantage is the poor quality of the final slide. It is used less in diagnostic pathology, but more in determining margin of a tumor during surgery.

Staining of the Processed Histology Slides

This can be done to slides processed by the chemical fixation or frozen section slides. To see the tissue under a microscope, the sections are stained with one or more pigments. The aim of staining is to reveal cellular components; counterstains are used to provide contrast.
The most commonly used stain in histopathology is a combination of hematoxylin and eosin. Hematoxylin is used to stain nuclei blue, while eosin stains cytoplasm and the extracellular connective tissue matrix pink. There are hundreds of various other techniques which have been used to selectively stain cells. Other compounds used to color tissue sections include safranin, Oil Red O, congo red, silver salts and artificial dyes. Histochemistry refers to the science of using chemical reactions between laboratory chemicals and components within tissue. A commonly performed histochemical technique is the Perls Prussian Blue reaction, used to demonstrate iron deposits in diseases like Hemochromatosis.

Recently, antibodies have been used to stain particular proteins, lipids and carbohydrates. Called immunohistochemistry, this technique has greatly increased the ability to specifically identify categories of cells under a microscope. Other advanced techniques include in situ hybridization to identify specific DNA or RNA molecules. These antibody staining methods often require the use of frozen section histology. Digital cameras are increasingly used to capture histopathological images.

Interpretation

The histological slides are examined under a microscope by a pathologist, a medically qualified specialist. This medical diagnosis is formulated as a pathology report describing the histological findings and the opinion of the pathologist. In the case of cancer, this represents the tissue diagnosis required for most treatment protocols.

For Human infected tissue Specimen Characterization, you can contact to:-Through Proper Channel:---

Dr Anshu Gupta
Associate Professor
Department of Pathology
IHBAS,Delhi

ULTRASONOGRAPHY TRAINING

The institute of Ultrasound Training runs a various short term courses on Sonography for the medical professionals in affliation with Jefferson Ultrasound Research and Education Institute,Jefferson University Hospital, Philadelphia, USA WWW.JEFFERSON.EDU/JUREI

Institute Address:-
DR. RANDHAWA'S ULTRASOUND TRANING & RESEARCH INSTITUTE
Head Office:7/1, Prem Nagar, Janakpuri, New Delhi, India
Ph: 91-11-25598680, 91-1125598224Cell: +919891085080, +919871869828E-mail: iout364@yahoo.com
Web Sites: http://www.instituteofultrasoundtraning.com/
http://www.ultrasound.net.in/
For Further Details:e-mail: Ms. Aashi Singh at iout364@yahoo.com

MY VISITING CARD

if any one have any neurological problem,feel free to take advice!!!!

STIMULATING ELECTRODES IN NEURAL TREATMENT

Novel micro array of microelectrodes will open a new window for understanding the mechanism of neural network activity, functions, and pathways of control and can be a useful tool for treatment of neural disorders, such as tremor, epilepsy, schizophrenia, anorexia, depression, chronic pain, dystonia, movement disorders and Parkinson’s disease. Moreover, unlike the commercially available microelectrode of deep brain stimulation. These array provides fine stimulation with high resolution without side effects and uncontrolled electrical fields distributions.

For More Info,click on the given link :-

http://nano-biosensors.com/?cid=7&pid=scientific

Scorpion Venom Plus Nanoparticles Fight Brain Cancer

Compounds inside scorpion venom have come under intense scientific scrutiny over the years, since it was discovered that certain combinations had the ability to stop the spread of brain-cancer tumors. By combining this knowledge with recent advancements in nanoparticle technologies, researchers at the University of Washington (UW) have created a substance that is able to fight the spread of tumors with a 98-percent efficiency, as opposed to the 45 percent registered when using venom alone.

The active ingredient inside the venom is a small peptide known as chlorotoxin, which has been in use for quite some time now. It acts by binding with certain proteins, known as MMP-2, that are over-expressed by tumors, and annihilates the cancer's ability to spread. When chlorotoxin and MMP-2 bind, they are both sucked in the cancerous cell and, deprived of it's external “agent,” the tumor cannot grow.

For More Info,Click on the given links:-

http://web.singnet.com.sg/~chuaeecc/venom/venomcompo.htm

http://www.sciencedaily.com/releases/2009/04/090416133816.htm

http://www.telegraph.co.uk/scienceandtechnology/science/sciencenews/3352716/Radioactive-scorpion-venom-could-be-used-to-fight-brain-cancer.html

Nanoparticles illuminate brain tumors for days under MRI

A research team is demonstrating some of the world's first clinical applications for nanometer-size particles in the brain. The scientists have shown that an iron oxide nanoparticle as small as a virus can outline not only brain tumors under magnetic resonance imaging, but also other lesions in the brain that may otherwise have gone unnoticed, according to a study published in the journal Neuropathology and Applied Neurobiology.From the Oregon Health & Science University :Nanoparticles illuminate brain tumors for days under MRI.

MOVEMENT DISORDER TREATMENT

Botulinum Toxin Injections which are used  for the treatment of Movement disorder are available at Institute of Human Behavior and Allied Sciences , Delhi  . IHBAS is  one of the reputed Institutes in Northern India which deals in the treatment of various neurological/Psychiatric/Psychological disorders.It having well qualified  medical  and paramedical professionals who are fully dedicated in the  patient care services . Beside this, it have the  facility of  High Tech Instruments in Neuro-Electrophysiology Lab for the early detection of Epileptiform Discharges /Seizure Activity,Nerve Disorders and Apnea/Snooring Disorders.

Any needy person who is affected from  movement disorder   can approach to IHBAS,Delhi for intake the facility  of Botulinum Toxin Injection (http://en.wikipedia.org/wiki/Botulinum_toxin)

Feel free to contact from  the concern person for Botulinum Toxin injections:- 

Dr Suman Kushawaha

M.D,D.M(Neurology)

Associate Professor

IHBAS,Delhi,India

Speciality : Treating  differnt Neurological Disorders eg Epilepsy etc

OPD Schedules at IHBAS : Monday,Thursday,Friday at Room No:18

Official Sitting :Room No-112,1st Floor,Academic Block,IHBAS,Delhi

Email  : sumankushwaha@gmail.com

url       :http://ihbas.delhigovt.nic.in/

NOTE : 

!!MENTAL ILLNESS ARE TREATABLE!!

!!Intimate your Physician if any side effect arise from Prescribed Medicines !!                         

M.Tech(Nano) Interaction Programme 2009 in Jamia Miilia Islamia

   

                                                               

  

 Prof Mushahid Hussain

Co-ordinator, M.Tech(Nanotechnology) Prog'm

Dept of Physics,Jamia Millia Islamia,Delhi

http://www.jmi.nic.in/Fnat/mush_ph.htm

 Sucessfully Done M.Tech (Nano) Projects Interaction Programme 2009

Date           : 23 May 2009

Venue        : Seminar Hall ,Dept of Physics, J.M.I

Timings     : 9.30 AM to 2.00 PM 

Organiser : Prof Mushahid Hussain

Masters of Technology was started in Department of Physics,Jamia Millia Islamia in 2007 and successfully continue till now.Now Final Year students of the 2007 Batch of this course is ready to get job/to do reasearch after specialized in this field.For this , the co-ordinator of M.Tech(Nanotechnology) organized a Interaction programme between the final Year and Previous Year students on 23 May .Beside this various scientist are also invited from NPL and DRDO who gave their lectures on different R&D  activities carried out in the field of Nanotechnology. 

Participating Delegates:-

From Jamia Milllia Islamia:-

Prof Syed Sajjad Mehndi (HoD,Dept of Physics) 

Prof Mushahid Hussain  (Co-ordinator-M.Tech(Nano) programme

Prof Mohd Abdul Wahab

Prof Mohd Zulfiqar Zulfiqar

Prof Ayub Khan,D.U (Guest faculty in JMI)

Dr Saeeduddin

Dr Azher Majid Siddique

Phd Scholors of JMI

M.Tech (Nano) Sudents of First and Second Year.

 

Participating  scientist of DRDO and NPL:

 Prof Krishnan Lal (Emiretus Scientist) ,Former Director NPL

Dr Harsh ,SSPL,DRDO

Dr R.P Pant ,NPL

Dr M.N.Kamalasanan

Dr T.D Senguttuvan

Dr Sanjay Srivastava

 

TOPICS COVERED :-

 Synthesize and characteization of CNT and its Modelling and Simulation, 

Synthesize and Characterization of Zno Nanoparticles,  

Nanomagnetic Materials and its  Applications,

X-Ray Diffraction,Organic LEDs ,

NanoCeramics and its applictions ,

Silcon Nanowires,Purification Of CNT's